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H-Y antigen
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H-Y antigen : ウィキペディア英語版
H-Y antigen
H-Y antigen is a male tissue specific antigen.〔 Originally thought to trigger the formation of testes, it is now known that it doesn't trigger the formation of testes but may be activated by the formation of the male testes.〔 In its production, there are at least two loci involved, an autosomal gene that generates the antigen and one that generates the receptor. 〔H-Y Antigen -- Medical Definition ()〕
The H-Y antigen secreted by the testis is identical to müllerian-inhibiting substance.〔
==Association with spermatogenesis==
It has been shown that male mice lacking in the H-Y antigen, hence lacking in the gene producing it, have also lost genetic information responsible for spermatogenesis.〔 This result also identified a gene on the mouse Y chromosome, distinct from the testis-determining gene, that was essential for spermatogenesis, thus raising the possibility that the very product of this "spermatogenesis gene" is the H-Y antigen.〔

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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